22 تیر 1399
فريبرز رحيمي

فریبرز رحیمی

مرتبه علمی: استادیار
نشانی:
تحصیلات: دکترای تخصصی / مهندسی برق-کنترل و مهندسی پزشکی
تلفن:
دانشکده: دانشکده فنی و مهندسی
گروه: گروه مهندسی برق

مشخصات پژوهش

عنوان
Synthesis and characterization of novel P (HEMA-LA-MADQUAT) micelles for co-delivery of methotrexate and Chrysin in combination cancer chemotherapy
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
drug delivery, co-polymer, cancer
پژوهشگران سودابه داوران (نفر اول)، حامد فاضلی (نفر دوم)، عالیه غمخواری (نفر سوم)، فریبرز رحیمی (نفر چهارم)، ام لیلا مولوی (نفر پنجم)، مریم انزابی (نفر ششم به بعد)، رویا صالحی (نفر ششم به بعد)

چکیده

A Novel poly [2-hydroxyethyl methacrylate-Lactide-dimethylaminoethyl methacrylate quaternary ammonium alkyl halide] [P(HEMA-LA-MADQUAT)] copolymer was synthesized through combination of ring opening polymerization (ROP) and ‘free’ radical initiated polymerization methods. This newly developed copolymer was fully characterized by FT-IR, 1HNMR and 13CNMR spectroscopy. Micellization of the copolymer was performed by dialysis membrane method and obtained micelles were characterized by FESEM, dynamic light scattering (DLS), zeta potential (ξ), and critical micelle concentration (CMC) measurements. This copolymer was developed with the aim of co-delivering two different anticancer drugs: methotrexate (MTX) and chrysin. In vitro cytotoxicity effect of MTX@Chrysin-loaded P(HEMA-LA-MADQUAT) was also studied through assessing the survival rate of breast cancer cell line (MCF-7)