March 29, 2024
Fariborz Rahimi

Fariborz Rahimi

Academic rank: Associate professor
Address: bonab - university of bonab
Education: Ph.D in ٍElectrical Engineering- Biomedical Engineering
Phone: 04137745000-1630
Faculty: Faculty of Engineering
Department: Electrical Engineering

Research

Title
Synthesis and characterization of novel P (HEMA-LA-MADQUAT) micelles for co-delivery of methotrexate and Chrysin in combination cancer chemotherapy
Type Article
Keywords
drug delivery, co-polymer, cancer
Researchers soodabeh davaran، Hamed Fazeli، Aliyeh Ghamkhari، Fariborz Rahimi، Ommoleila Molavi، Maryam Anzabi، Roya Salehi

Abstract

A Novel poly [2-hydroxyethyl methacrylate-Lactide-dimethylaminoethyl methacrylate quaternary ammonium alkyl halide] [P(HEMA-LA-MADQUAT)] copolymer was synthesized through combination of ring opening polymerization (ROP) and ‘free’ radical initiated polymerization methods. This newly developed copolymer was fully characterized by FT-IR, 1HNMR and 13CNMR spectroscopy. Micellization of the copolymer was performed by dialysis membrane method and obtained micelles were characterized by FESEM, dynamic light scattering (DLS), zeta potential (ξ), and critical micelle concentration (CMC) measurements. This copolymer was developed with the aim of co-delivering two different anticancer drugs: methotrexate (MTX) and chrysin. In vitro cytotoxicity effect of MTX@Chrysin-loaded P(HEMA-LA-MADQUAT) was also studied through assessing the survival rate of breast cancer cell line (MCF-7)