جواد یکرنگ

Abstract Objective: The possibility of fabrication of sage seed gum based nanofiber scaffold and investigating some of its mechanical, rheological and physicochemical properties for identification of its functions in various fields of medical sciences. Material and methods: Sage seed gum was extracted and distilled water was used for preparation of its solution. Based on the Taguchi method, 9 electrospinning specimens with 3 electrospinning factors (feed rate, voltage and spinning distance) were fabricated by combining PVA/SSG (30:70, 40:60 and 50:50). PVA was applied as assistant polymer for facilitation of spinning. Based on experimental design, the influence of aforementioned factors on morphological, hydropathy, mechanical and rheological preoperties as well as FT-IR characteristics of the nanofibers were assessed. Results and discussion: The SEM micrographs demonstrated that uniform fibers have been produced with average diameter of 240 nm. The scaffolds with higher level of incorporation of SSG showed more hydrophilicity……. Conclusion: The results of present research proved the ability of application of SSG in combination with PVA for fabrication of scaffolds with potential for medical and pharmaceutical uses. Keywords: Electrospinning, Nanofiber, Sage seed Biopolymer, Biodegradable polymers, Rheological properties