Synergic effect of Pt-Co nanoparticles and a dopamine derivative in a nanostructured electrochemical sensor for simultaneous determination of N-acetylcysteine, paracetamol and folic acid, By Mehdi Hatami

Research

Title	Synergic effect of Pt-Co nanoparticles and a dopamine derivative in a nanostructured electrochemical sensor for simultaneous determination of N-acetylcysteine, paracetamol and folic acid
Type	Article
Keywords	Electroanalysis . Nanomaterial . Carbon paste electrode . X-ray diffraction . Electrochemical impedance spectroscopy . Square wave voltammetry . Electrooxidation . X-ray diffraction . Energy dispersive X-ray analysis
Researchers	Hassan Karimi-Maleh، Mehdi Hatami، Reza Moradi، Mohammad A. Khalilzadeh، Sedigheh Amiri، Hasan Sadeghifar

Abstract

A carbon paste electrode (CPE) was modified with Pt-Co nanoparticles and 2-(3,4- dihydroxyphenethyl)isoindoline-1,3-dione (3,4-DHPID) and then used for determination of N-acetylcysteine (N-AC) in the presence of paracetamol (PC) and folic acid (FA). The Pt-Co nanoparticles were synthesized by the polyol method and characterized by X-ray diffraction, energy dispersive Xray analysis and transmission electron microscopy. The modified CPE displays good electrocatalytic activity towards the electrooxidation of N-AC in solution of pH 7.0. It was applied to the determination of N-AC in the presence of PC and FA (with well separated signals peaking at 0.2, 0.55 and 0.86 V vs. Ag/AgCl) by using square wave voltammetry. The peak currents are linearly dependent on the concentrations of NAC, PC and FA in the respective ranges from 0.07 to 500, 1.0 to 850, and 2.0 to 550 μmol·L−1 , with detection limits of 0.009, 0.6 and 0.8 μmol·L−1 . The modified CPE was applied to the determination of N-AC, PC and FA in (spiked) pharmaceutical and biological samples.