Acute injuries or wound requires fast delivery of drug to control and remove infections without any side effect.
This work developed biodegradable nanofibrous antibiotic-eluting scaffolds from poly lactic glycolic acid
(PLGA) and gum tragacanth (PLGA/GT) which produced sustained release pattern of tetracycline
hydrochloride from transdermal patch for repairing slow rate healing wounds such as injuries in the patients
with diabetic disorder. Blend nanofibers were prepared using various blend ratios of PLGA/GT (100/0, 75/25,
50/50) with 5% (w/v) of drug. Scanning electron microscopy (SEM) results showed that fabricated PLGA,
blend PLGA/GT nanofibers had a smooth and bead-less morphology with the diameter ranging from 180 to
460 nm. In vitro drug release studies showed that the fraction of GT within blend nanofibers can effectively
control TCH release rate from the nanofibrous membranes and for PLGA/GT 75:25 drug release was sustained
for 25 day with only 24% of burst release within the first 2h. The prolonged drug release, together with proven
biocompatibility and biodegradation property of drug loaded nanofibers make the PLGA/GT 75/25 scaffold as
a promising candidate to be used as drug delivery system for regeneration of slow rate wounds.