مرضیه رنجبر محمدی

Electrospun membranes presents some unique features, such as high specific surface area, high porosity, superior mechanical performance and morphological similarity to natural extracellular matrix (ECM) that justifies their application in drug delivery, tissue engineering and wound dressing [1]. We report fabrication biomedical electrospun nanofibrous scaffold based on a Gum Tragacanth (GT), poly (vinyl alcohol) (PVA) and poly (ε-caprolactone) (PCL) through double nozzle Electrospinning processes. So that aqueous solution of PVA/GT (blend ratio: 60:40) [2] was injected from one syringe and PCL solution from the other one. GT is a biocompatible natural biopolymer which has been used in this study because of its biodegradability property, non-toxic characteristic, natural availability, microbial resistance [2, 3]. Present of PVA and PCL in formulation improve the electrospinning process of GT solution and mechanical properties of the fabricated nanofibers, respectively. Tragacanth shows great potential as carrier for keeping and delivery of drugs [4]; so 5wt% hydrophilic tetracycline hydrochloride (TCH) was added into PVA/GT solution. Scanning electron microscopy (SEM) was used to investigate the morphology and average diameter of the nanofibers. Antibacterial, hydrophilicity and biodegradation properties of nanofibers were evaluated. In vitro tetracycline release was studied for 48 hours in phosphate buffer solution. Results showed that uniformly distribution of PCL nanofibers among other fibers containing drug and tragacanth there is sufficient opportunity and control for drug delivery. The controlled drug release, hydrophilicity, antibacterial and biodegradation properties, resulted in production of scaffolds which are suitable for wound healing applications.