رضا حاجی آقائی وفائی

Purpose The on-chip high-throughput mixing process is one of the main challenges in the preparation process in clinical diagnostics. Because of high laminar flow in micro-channel, the fluid should be disturbed by external force. This paper aims to study pulsed AC electrothermal flow and the multiphysic interaction between the fluid behavior, external electric field, temperature field and convection-diffusion field to generate perturbation effect inside the channel. Design/methodology/approach A set of numerical simulations were carried out by multiphysic interactions between the fluid behavior, external electric field, temperature field and convection-diffusion field to generate the pulsed AC electrothermal flow inside the channel. Behavior of electrode–electrolyte system is discussed using the electrical lumped circuit model. Findings Highly efficient temperature gradients are generated by applying pulsed electric potential over the electrodes; as a result, efficient secondary flows form inside the channel. The proposed method increases the interfacial contact area between the fluids and enhances the molecular diffusion transport phenomena. Maximum temperature rise of 4.1 K is observed in the gap between the electrodes for 0.08 S/m fluid medium, where the electric field is much stronger than elsewhere. Velocity field and concentration analysis reveal high performance perturbation effects for the mixing process. The periodic stretching and folding effects increase the interfacial contact area between the fluids by using pulsed AC electrothermal flow. Based on the results, 83 per cent mixing efficiency is achieved for 0.08 S/m fluid medium with a microchannel length of 400 µm. Both the mixing efficiency and generated temperature rise increase by increasing the fluid ionic strength. Originality/value The ability to generate low temperature rise is very important for AC electrothermally driven fluidic chips such as immunoassay chips. In the present research, a novel ac