The purpose of this research is to introduce and design scaffolds composed of polycaprolactone(PCL)
and gelatine nanofibers containing both hydroxyapatite and graphene nanoparticles at the same time
for using in bone tissue engineering. At first, optimal conditions for the production of PCL/gelatine
nanofibrous webs were investigated. In the following step, hydroxyapatite and graphene nanoparticles
incorporated into PCL/gelatine nanofibrous webs for comparison with PCL/gelatine nanofibrous webs
without adding any particles. Morphological, mechanical and biological tests were done to analyse
fabricated structures. 50%PCL/50%gelatin sample has the less fiber diameter in both group with or
without adding nanoparticles of hydroxyapatite and graphene. The FTIR analyses revealed characteristic absorption bands for PCL/gelatin/hydroxyapatite/graphene nanofibrous scaffolds is still similar to
that of PCL/gelatin sample. Also, blending of PCL with gelatin decreased tensile strength and
increased the tensile strain. As the final result, the addition of hydroxyapatite and graphene reduces
diameter of nanofiber and improves the biological and mechanical properties and has a good potential using in bone tissue engineering