Background: Road traffic accidents remain a leading cause of injuries and fatalities worldwide, with human error as a major contributing factor. Advanced Driver Assistance Systems (ADAS) play a crucial role in reducing such accidents by supporting drivers in the decision-making process. However, drivers’ awareness, perception, and trust in ADAS are critical to ensuring their effective use. Aims: The aim of this study was to assess the level of awareness, perception, and trust regarding ADAS among drivers in Tabriz, Iran, and to identify the demographic and vehicle-related factors influencing these variables. Methods: This study used a cross-sectional survey design with a quantitative approach. A self-administered questionnaire was distributed among 450 drivers. The data were analyzed using descriptive statistics, chi-square tests, Pearson correlations, and ordinal logistic regression models to determine significant relationships and predictive factors. Results: The results of the present study revealed that gender, age, driving experience, and vehicle type significantly influenced drivers’ awareness of ADAS. A strong positive correlation was found between ADAS awareness and the level of trust in the system (r = 0.62, p < 0.001). Ordinal logistic regression analysis showed that demographic factors significantly predicted ADAS awareness, explaining 37% of the variance (Pseudo R² = 0.37). Conclusions: Drivers’ awareness and perception of ADAS are influenced by several key demographic and vehicle-related factors. Promoting educational and advertising campaigns may enhance knowledge and trust in these technologies, ultimately improving road safety and reducing traffic accidents.