Marziyeh Ranjbar-Mohammadi

Acute injuries or wound requires fast delivery of drug to control and remove infections without any side effect. This work developed biodegradable nanofibrous antibiotic-eluting scaffolds from poly lactic glycolic acid (PLGA) and gum tragacanth (PLGA/GT) which produced sustained release pattern of tetracycline hydrochloride from transdermal patch for repairing slow rate healing wounds such as injuries in the patients with diabetic disorder. Blend nanofibers were prepared using various blend ratios of PLGA/GT (100/0, 75/25, 50/50) with 5% (w/v) of drug. Scanning electron microscopy (SEM) results showed that fabricated PLGA, blend PLGA/GT nanofibers had a smooth and bead-less morphology with the diameter ranging from 180 to 460 nm. In vitro drug release studies showed that the fraction of GT within blend nanofibers can effectively control TCH release rate from the nanofibrous membranes and for PLGA/GT 75:25 drug release was sustained for 25 day with only 24% of burst release within the first 2h. The prolonged drug release, together with proven biocompatibility and biodegradation property of drug loaded nanofibers make the PLGA/GT 75/25 scaffold as a promising candidate to be used as drug delivery system for regeneration of slow rate wounds.