The solubility of carbon dioxide in water is measured at 278.15–348.15 K and 0.1–1 MPa. The experimental data are compared with those obtained from equations of state such as van der Waals, Redlikh-Kwong, Soave- Redlikh-Kwong, Peng-Robinson coupled with two mixing rules van der Waals and Wong Sandler equations. Also, the solubility of carbon dioxide in water is modeled using the artificial neural network system and optimized with genetic algorithm method. The results show that the artificial neural network system can accurately predict the solubility of carbon dioxide in water than the other equations of state.