In this investigation, curcumin niosomal nanoparticles were prepared via a simple, efficient and eco-friendly route, thin film hydration (TFH), in the presence of different mixture of the surfactants (tween 60 and span 60). Cholesterol ratio to surfactant, as effective factor, was altered to obtain the optimal nanoparticles. The size, zeta potential, size distribution, entrapment efficiency of the prepared nanoparticles were examined and compared. The optimum nanoparticles were chosen to examine the release from the dialysis membrane. Ratio of cholesterol to surfactant was found to have key and notable influence on the size, zeta potential, size distribution and entrapment efficiency of the prepared nanoparticles. The nanoparticles prepared with Formulations 3 and 5 as optimum nanoparticles were chosen to examine the release from the dialysis membrane. The results denoted that by increasing the ratio of cholesterol to surfactant, the rate of curcumin release was enhanced from the membrane. High quantities of cholesterol in the formulation 3, in addition to explosive release, can lead to slow release.
