In this study, the synthesis of the sponge-like (SL) Pr2Ce2O7 nanostructures was performed in the presence of a new and green capping agent, sucrose, to control the particle size and achieve a well-organized oxide nanostructure. Various techniques characterized the obtained nanocomposites. According to scanning electron microscopy (SEM) images, the new nanocomposite's surface displayed a homogenous and well-dispersed state. For the electrochemical analysis of pramipexole (PMX) at pH 6.0, the prepared nanocomposite and an ionic liquid were utilized to modify the carbon paste electrode (CPE). Comparison of response at the bare and SL-Pr2Ce2O7/IL/CPE utilizing cyclic (CV) showed synergistic effects of SL-Pr2Ce2O7 and ionic liquid in reducing the potential needed for PMX oxidation, as well as increasing the current response signal. This modified electrode exhibited a linearity between the oxidation signal and the PMX concentration in the range of 0.2–360 µM. Furthermore, the developed electrode possesses a low limit of detection (LOD) of 0.04 µM with suitable electrocatalytic behavior and acceptable stability for PMX detection. In addition, SL-Pr2Ce2O7/IL/CPE represents good repeatability, selectivity, and reproducibility. Finally, the modified electrode can detect PMX in tablets, urine, and human blood serum successfully.
