July 10, 2020
Fariborz Rahimi

Fariborz Rahimi

Academic rank: Assistant professor
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Education: Ph.D in ٍElectrical Engineering-Control & Biomedical Engineering
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Faculty: Faculty of Engineering
Department: Electrical Engineering

Research

Title
The dopaminergic system in upper limb motor blocks (ULMB) investigated during bimanual coordination in Parkinson’s disease (PD)
Type Article
Keywords
Dopaminergic system, upper limb, Parkinson’s disease (PD), bimanual coordination
Researchers Matt J.N. Brown، Quincy J. Almeida، Fariborz Rahimi

Abstract

Upper limb motor blocks (ULMB) (inability to initiate or sudden discontinue in voluntary movements) have been identified in both unimanual and bimanual tasks in individuals with Parkinson’s disease (PD). In particular, ULMB have been observed during rhythmic bimanual coordination when switching between phase patterns which is required (e.g. between in-phase and anti-phase). While sensory-perceptual mechanisms have recently been suggested to be involved in lower limb freezing, there has been no consensus on the mechanism that evokes ULMB or whether motor blocks respond to dopamine replacement like other motor symptoms of PD. The current study investigated the occurrence of ULMB in PD participants without (‘off’) and with (‘on’) dopamine replacement using bimanual wrist flexion—extension with external auditory cues.