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Title
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Fabrication and characterization of cobalt- and copper-doped mesoporous borate bioactive glasses for potential applications in tissue engineering
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Type
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JournalPaper
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Keywords
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Mesoporous bioactive glass (MBGs)Borate glassesData scienceBiocompatibilityTissues engineering
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Abstract
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Developing novel compositions of bioactive glasses (BGs) is key for accelerating tissue repair and regeneration. In this work, we developed a series of cobalt (Co)- and copper (Cu)-doped mesoporous bioactive glasses (MBGs) based on borate 13-93B3 composition using nitrate precursors. We took benefit from data science algorithms to predict and assess the physico-chemical and biological properties of the samples. The results showed that the presence of the dopants (Co and Cu) in the MBGs could change the glass transition temperature (Tg) (from 773 to 539 °C), the zeta potential (from -12 to -43 mV), and surface area (from 54 to 194 m2/g). However, the presence of 2.5 mol% of dopants in the composition led to just a slight decrease in their bioactivity. In vitro biocompatibility assays confirmed that all the glass samples were biocompatible. Furthermore, the doped MBGs exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria. In addition, these glasses could induce the mobility of human umbilical vein endothelial cells (HUVECs) and enhance new blood vessel formation in ovo. According to the obtained data, it can be stated that this type of doped borate MBGs held great promise in tissue engineering applications.
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Researchers
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Saeid Kargozar (Not In First Six Researchers), Francesco Baino (Not In First Six Researchers), Kai Zheng (Not In First Six Researchers), Simin Nazarnezhad (Not In First Six Researchers), Seyede Atefe Hosseini (Not In First Six Researchers), Zahra Mollaei (Not In First Six Researchers), Bahman Jalali-Kondori (Not In First Six Researchers), Marziyeh Ranjbar-Mohammadi (Not In First Six Researchers), Alireza Sadeghi-Avalshahr (Fifth Researcher), Fatemeh Alipour (Fourth Researcher), Sahar Mollazadeh (Third Researcher), Farzad Kermani (Second Researcher), Zoleikha Azari (First Researcher)
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