مشخصات پژوهش

صفحه نخست /Development of biodegradable ...
عنوان Development of biodegradable electrospun gelatin/aloe-vera/poly (ε‑caprolactone) hybrid nanofibrous scaffold for application as skin substitutes
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها ElectrospinningNanofiberGelatinPCLAloe-veraSkin tissue engineering
چکیده Nowadays, aloe-vera (AV) is exploited extensively in nanofibrous structures for skin substitutes. However, the lack of electrospinnability and appropriate mechanical characteristics are the key limitations for this natural extract to be used in the form of nanofibrous mats. In this study, two commercially available biopolymers, gelatin (Gel) and poly(ε‑caprolactone) (PCL), were chosen to improve these issues and double-nozzle electrospinning technique was used to fabricate hybrid scaffold from Gel/AV blend and PCL solutions. Response surface methodology was utilized to investigate the effect of electrospinning parameters (Gelatin concentration, Aloe-vera concentration and Gel/AV feed-rate) on the mechanical properties, morphology and hydrophilicity of nanofibers and the optimized scaffold was chosen for further studies. In order to verify the application of this scaffold in bioapplications, the chemical, thermal and …
پژوهشگران مرضیه رنجبر محمدی (نفر سوم)، هژیر بهرامی (نفر دوم)، پیمان باروکی میلان (نفر پنجم)، سمیه باقرصاد (نفر اول)، محمدرضا محدث مجتهدی (نفر چهارم)