مشخصات پژوهش

صفحه نخست /Fabrication and ...
عنوان Fabrication and characterization of cobalt- and copper-doped mesoporous borate bioactive glasses for potential applications in tissue engineering
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها Mesoporous bioactive glass (MBGs)Borate glassesData scienceBiocompatibilityTissues engineering
چکیده Developing novel compositions of bioactive glasses (BGs) is key for accelerating tissue repair and regeneration. In this work, we developed a series of cobalt (Co)- and copper (Cu)-doped mesoporous bioactive glasses (MBGs) based on borate 13-93B3 composition using nitrate precursors. We took benefit from data science algorithms to predict and assess the physico-chemical and biological properties of the samples. The results showed that the presence of the dopants (Co and Cu) in the MBGs could change the glass transition temperature (Tg) (from 773 to 539 °C), the zeta potential (from -12 to -43 mV), and surface area (from 54 to 194 m2/g). However, the presence of 2.5 mol% of dopants in the composition led to just a slight decrease in their bioactivity. In vitro biocompatibility assays confirmed that all the glass samples were biocompatible. Furthermore, the doped MBGs exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria. In addition, these glasses could induce the mobility of human umbilical vein endothelial cells (HUVECs) and enhance new blood vessel formation in ovo. According to the obtained data, it can be stated that this type of doped borate MBGs held great promise in tissue engineering applications.
پژوهشگران مرضیه رنجبر محمدی (نفر ششم به بعد)، سعید کارگذار (نفر ششم به بعد)، زلیخا آذری (نفر اول)، فرزاد کرمانی (نفر دوم)، سحر ملازاده (نفر سوم)، فاطمه علی پور (نفر چهارم)، علیرضا صادقی اول شهر (نفر پنجم)، بهمن جلالی کندری (نفر ششم به بعد)، زهرا ملایی (نفر ششم به بعد)، سیده عاطفه حسینی (نفر ششم به بعد)، سیمین نظرنژاد (نفر ششم به بعد)، کای ژنگ (نفر ششم به بعد)، فرانسیسکو باینو (نفر ششم به بعد)