مشخصات پژوهش

صفحه نخست /Chitosan-based pH-sensitive ...
عنوان Chitosan-based pH-sensitive antibacterial bionanocomposites with laponite immobilized silver nanoparticles for delivery of sunitinib maleate to breast cancers
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها Chitosan-based pH-sensitive antibacterial bionanocomposites with laponite immobilized silver nanoparticles for delivery of sunitinib maleate to breast cancers
چکیده In this work, new pH-sensitive and antibacterial drug carrier systems based on silver nanoparticles (AgNPs) embedded in the interlayer of laponite (Lap) in the presence of chitosan (CTS) for the controllable release of sunitinib maleate (STM) were developed. Silver ions and sunitinib maleate were first loaded into Lap, and the CTS-based hybrid bionanocomposite carrier (Lap@CTS@AgNPs@STM) was obtained in the presence of citric acid as a cross-linker agent. The successful preparation of nanocarrier and Ag NPs formation was thoroughly confirmed using techniques such as FTIR, XRD, TGA, SEM, and TEM. TEM images illustrated the excellent distribution of Ag NPs in the structure of Lap@CTS@AgNPs. The as-prepared samples showed a pHsensitive anticancer drug release behavior. The STM release mechanism was studied using Korsmeyer–Peppas and Higuchi kinetic models. Furthermore, the in vitro cytotoxicity and antibacterial tests were carried out against both bacteria S. aureus and E. coli and MCF-7 cell lines, respectively, to prove the effectiveness of synthesized samples as multifunctional carrier systems for biomedical applications.
پژوهشگران زهرا سیار (نفر پنجم)، غلامرضا مهدوی نیا (نفر دوم)، پریسا لبیب (نفر اول)، آرزو دهقانی (نفر سوم)، رئوف ستاری نوبرزاد (نفر چهارم)، حسام جعفری (نفر ششم به بعد)، خشایار نجف زاده (نفر ششم به بعد)، علی اکبری (نفر ششم به بعد)